...after taking a bite out of one of the fruits from the "tree of knowledge"...
Adam and Eve looked around, and, upon seeing they were naked, felt ashamed ...

One take I have on this passage is that up until the time they took a bite of the apple their whole world was just them, the Garden of Eden, and experiencing full "favoritism from God".

Once knowledge entered their mind they became more aware of everything around them, and that there's more to reality than just their provincial perspectives, that they're not "the center of" all that is, but, rather, just an integral part of everything in existence---simply just a part of the whole.

Suddenly realizing they actually don't matter as much as they always thought they did, it brought upon them feelings of insecurity, of vulnerability, of no longer "mattering" enough to be worthy of any special "protection" or "preferential considerations" from God above.

"Naked" could be considered a metaphor for no longer feeling "protected" or "favored by God", now that they've figured out they might actually be "just one-in-a-million among all the other creations" and not the special "God's chosen ones" they so long assumed themselves to be all the while.